Histone H3: A Potential Drug Target Or Biomarker (P11326)

Target Name: Histone H3

NCBI ID: P11326

Histone H3

Other Name(s): None

Histone H3: A Potential Drug Target Or Biomarker

Histone H3, also known as histone H3.1, is a type of histone that is found in the nuclei of all living cells. Histones are small, positively charged proteins that play a critical role in the regulation of gene expression. They are composed of four subtypes, H1, H2A, H2B, and H3, each with a different degree of acidity. Histone H3 is the least acidic of the histone subtypes and is composed of 184 amino acid residues.

Histone H3 is involved in the regulation of various cellular processes, including cell growth, differentiation, and DNA replication. It has been shown to play a role in the regulation of gene expression and has been linked to the development and progression of various diseases, including cancer. As a result, histone H3 has become a focus of interest for researchers and may be a potential drug target or biomarker.

One of the key functions of histone H3 is its role in the regulation of gene expression. Histones can interact with specific DNA sequences to control the access of transcription factors to the gene of interest. This interaction is known as epigenetic modulation and is a critical mechanism for the regulation of gene expression.

Histone H3 has been shown to play a role in the regulation of gene expression in various organisms, including humans. For example, studies have shown that histone H3 can interact with the gene promoter of the oncogene P21 and that this interaction can modulate gene expression. Similarly, histone H3 has been shown to interact with the tumor suppressor gene TP53 and that this interaction can modulate the response to DNA damage in cancer cells.

In addition to its role in gene expression, histone H3 has also been shown to play a role in the regulation of cellular processes that are important for tissue growth and development. For example, studies have shown that histone H3 can play a role in the regulation of cell adhesion and that this interaction can be modulated by various factors, including the level of cytoplasm in the cells and the mechanical forces applied to the cells.

Histone H3 has also been shown to play a role in the regulation of DNA replication. Histones can interact with DNA to control the access of the DNA replication machinery to the replication fork and this interaction can modulate the efficiency of DNA replication.

In conclusion, histone H3 is a critical protein that plays a critical role in the regulation of gene expression and cellular processes. Its role in the regulation of gene expression and cellular processes makes it an attractive target for research and may lead to the development of new treatments for various diseases. While further research is needed to fully understand the functions of histone H3, its potential as a drug target or biomarker is already clear.

Protein Name: Histone H3 (nonspecified Subtype)

The "Histone H3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Histone H3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets